Scheme 3. ESI mass analysis of the reaction mixture of 1c and 2b after grinding in a ball mill in the presence of 1,5-cod. Conditions: 1c (0.3 mmol), 2b (0.36 mmol), Pd(OAc)2 (0.009 mmol), DavePhos (0.0135 mmol), CsF (0.9 mmol), H2O (20 μL), and 1,5-cod (0.12 μL mg–1) in a stainless-steel ball-milling jar (1.5 mL) with a stainless-steel ball (5 mm).
