Table 3. Cytotoxic activities of benzochalcones against MCF-7, MDA-MB-231, LCC6/P-GP and MCF-7 cell lines.
Cmpd. | IC50 values (μM) |
|||
MCF-7 | MDA-MB-231 | LCC6/P-gp | MCF-7/1B1 | |
1 | 25.9 ± 3.2 | 46.2 ± 5.3 | >100 | 32.3 ± 4.5 |
2 | 25.8 ± 4.1 | 37.8 ± 2.8 | 29.8 ± 2.6 | 65.1 ± 4.1 |
3 | 29.1 ± 3.9 | 66.4 ± 4.4 | 67.3 ± 3.9 | 33.8 ± 4.1 |
4 | 48.1 ± 3.7 | 79.6 ± 4.9 | 48.6 ± 2.9 | >100 |
5 | 20.6 ± 2.2 | 43.5 ± 3.6 | 12.2 ± 2.7 | 42.4 ± 4.2 |
6 | 22.3 ± 1.2 | 37.6 ± 1.8 | 20.9 ± 2.0 | 41.3 ± 3.2 |
7 | 38.5 ± 2.9 | 65.3 ± 4.2 | 45.7 ± 5.3 | 48.4 ± 4.2 |
8 | 26.9 ± 3.1 | 43.9 ± 4.0 | 25.1 ± 3.8 | 26.4 ± 4.5 |
9 | 43.4 ± 1.6 | 75.3 ± 6.8 | 43.9 ± 4.4 | >100 |
10 | 1.8 ± 0.3 | 14.3 ± 0.8 | 7.7 ± 0.9 | 11.3 ± 0.8 |
ANF | 80.7 ± 7.6 | >100 | 82.3 ± 8.5 | >100 |
11 | 7.6 ± 0.7 | 19.8 ± 2.8 | 8.0 ± 2.3 | 12.7 ± 1.7 |
12 | 20.5 ± 1.3 | 25.7 ± 2.5 | 15.8 ± 2.4 | 14.8 ± 1.9 |
13 | 39.6 ± 4.1 | 48.7 ± 3.3 | >100 | >100 |
14 | 1.9 ± 0.4 | 62.2 ± 5.7 | 3.9 ± 0.4 | 43.8 ± 6.3 |
15 | 24.7 ± 2.1 | 34.1 ± 3.0 | 19.4 ± 2.7 | 18.2 ± 1.8 |
16 | 22.5 ± 2.8 | 35.2 ± 2.2 | 30.8 ± 1.9 | 45.5 ± 3.5 |
17 | 20.3 ± 1.2 | 35.5 ± 3.4 | 80.9 ± 6.2 | 23.8 ± 3.1 |
18 | 6.3 ± 1.4 | 15.8 ± 2.2 | 9.6 ± 1.3 | 15.1 ± 1.8 |
19 | >100 | >100 | >100 | >100 |
20 | 46.8 ± 4.7 | 48.9 ± 4.1 | >100 | 20.4 ± 3.3 |
5-FU | >100 | 93.8 ± 6.1 | >100 | >100 |