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. 2019 Jul 2;10(9):1606–1614. doi: 10.1039/c9md00258h

Table 3. Cytotoxic activities of benzochalcones against MCF-7, MDA-MB-231, LCC6/P-GP and MCF-7 cell lines.

Cmpd. IC50 values (μM)
MCF-7 MDA-MB-231 LCC6/P-gp MCF-7/1B1
1 25.9 ± 3.2 46.2 ± 5.3 >100 32.3 ± 4.5
2 25.8 ± 4.1 37.8 ± 2.8 29.8 ± 2.6 65.1 ± 4.1
3 29.1 ± 3.9 66.4 ± 4.4 67.3 ± 3.9 33.8 ± 4.1
4 48.1 ± 3.7 79.6 ± 4.9 48.6 ± 2.9 >100
5 20.6 ± 2.2 43.5 ± 3.6 12.2 ± 2.7 42.4 ± 4.2
6 22.3 ± 1.2 37.6 ± 1.8 20.9 ± 2.0 41.3 ± 3.2
7 38.5 ± 2.9 65.3 ± 4.2 45.7 ± 5.3 48.4 ± 4.2
8 26.9 ± 3.1 43.9 ± 4.0 25.1 ± 3.8 26.4 ± 4.5
9 43.4 ± 1.6 75.3 ± 6.8 43.9 ± 4.4 >100
10 1.8 ± 0.3 14.3 ± 0.8 7.7 ± 0.9 11.3 ± 0.8
ANF 80.7 ± 7.6 >100 82.3 ± 8.5 >100
11 7.6 ± 0.7 19.8 ± 2.8 8.0 ± 2.3 12.7 ± 1.7
12 20.5 ± 1.3 25.7 ± 2.5 15.8 ± 2.4 14.8 ± 1.9
13 39.6 ± 4.1 48.7 ± 3.3 >100 >100
14 1.9 ± 0.4 62.2 ± 5.7 3.9 ± 0.4 43.8 ± 6.3
15 24.7 ± 2.1 34.1 ± 3.0 19.4 ± 2.7 18.2 ± 1.8
16 22.5 ± 2.8 35.2 ± 2.2 30.8 ± 1.9 45.5 ± 3.5
17 20.3 ± 1.2 35.5 ± 3.4 80.9 ± 6.2 23.8 ± 3.1
18 6.3 ± 1.4 15.8 ± 2.2 9.6 ± 1.3 15.1 ± 1.8
19 >100 >100 >100 >100
20 46.8 ± 4.7 48.9 ± 4.1 >100 20.4 ± 3.3
5-FU >100 93.8 ± 6.1 >100 >100