Skip to main content
. 2019 Sep 17;78(11):1559–1565. doi: 10.1136/annrheumdis-2019-215210

Figure 3.

Figure 3

γδT-cells in enthesis and blood are transcriptionally distinct. Unmatched entheseal tissue derived subsets were compared with healthy blood derived cells. They had significantly higher expression of transforming growth factor β1 (TGFβ1), nuclear receptor subfamily 4 group a member 1 (Nr4a1) and lower expression of Krupple-like factor 2 (KLF2) and T-box 21 (TBX21) (A). All γδT-cell subsets expressed high levels of signal transduction molecules and immunomodulatory genes, Expression of IL-23/IL-17 axis cytokines was low or absent. Colour denotes relative expression to HPRT blue-low, black-equal, yellow-high, grey-below detection, Arrows indicate higher expression in γδT-cells (all subsets) from entheseal tissue (EST and PEB) compared with blood. Numbers show difference in median relative abundance. The ‘un-sorted’ category represents gene expression in an unsorted mixture of all cells released from entheseal digests (B) (PEB n=12, EST n=12, PB n=6). *P<0.05, **P<0.01. EST, entheseal soft tissue; PEB, peri-entheseal bone.