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. 2019 Nov 7;15(11):e1008059. doi: 10.1371/journal.ppat.1008059

Fig 2. The Mep2 transceptor undergoes a phosphorylation-dependent conformational change.

Fig 2

Trimer cartoon models viewed from the side for (left) wild-type Candida albicans Mep2 (CaMep2) and (right) a CaMep2 variant that mimics the phosphorylation of a regulatory serine residue (S453) within the cytoplasmic CTD that activates the transporter. The cartoons are in rainbow representation. The phosphorylation-mimicking CaMep2 variant has undergone a large conformational change, resulting in the formation of a 12-residue-long α-helix (red) in the CTD [19]. Changes in transceptor conformation may regulate its interaction with a signaling partner. CTD, C-terminal cytoplasmic domain.