Table 2. Identification of metabolites that differ depending on the level of HbA1c by a multivariate logistic regression analysis in the discovery set.
| Group | Metabolites | Odds Ratio (CI) | FDR-Corrected P-value |
|---|---|---|---|
| High Concentrations in the Normal HbA1c Group | Glutamine | 3.02 (2.15–4.38) | 1.00E-09 |
| Tryptophan | 2.94 (2.12–4.21) | 6.00E-10 | |
| Histidine | 2.65 (1.91–3.8) | 3.00E-08 | |
| Lysine | 2.27 (1.68–3.17) | 4.00E-07 | |
| Valine | 1.97 (1.49–2.65) | 4.00E-06 | |
| Threonine | 1.96 (1.48–2.66) | 7.00E-06 | |
| Methionine | 1.91 (1.44–2.59) | 1.00E-05 | |
| Tyrosine | 1.70 (1.30–2.27) | 2.00E-04 | |
| lysoPC a C16:1 | 1.63 (1.25–2.16) | 4.00E-04 | |
| Sarcosine | 1.59 (1.19–2.21) | 3.00E-03 | |
| lysoPC a C18:0 | 1.58 (1.22–2.09) | 8.00E-04 | |
| Glycine | 1.55 (1.19–2.03) | 1.00E-03 | |
| Serine | 1.52 (1.17–2.01) | 2.00E-03 | |
| Low Concentrations in the Normal HbA1c Group | PC aa C34:1 | 0.66 (0.48–0.87) | 5.00E-03 |
| PC ae C36:1 | 0.64 (0.48–0.84) | 2.00E-03 | |
| PC aa C28:1 | 0.64 (0.47–0.85) | 3.00E-03 | |
| Citrulline | 0.58 (0.41–0.77) | 6.00E-04 | |
| Spermidine | 0.57 (0.40–0.77) | 6.00E-04 | |
| PC aa C36:4 | 0.56 (0.40–0.75) | 3.00E-04 | |
| PC aa C26:0 | 0.51 (0.37–0.69) | 3.00E-05 | |
| PC aa C34:2 | 0.45 (0.31–0.63) | 7.00E-06 | |
| Hexose | 0.05 (0.02–0.11) | 2.00E-14 |