Table 3. Identification of metabolites with different concentrations depending on the level of HbA1c by a multivariate logistic regression analysis in the replication set.
| Group | Metabolites | Odds Ratio (CI) | FDR-Corrected P-value |
|---|---|---|---|
| High Concentrations in the Normal HbA1c Group | Threonine* | 3.77 (2.38–6.32) | 9.00E-08 |
| Lysine* | 3.22 (2.02–5.46) | 4.00E-06 | |
| Histidine* | 2.97 (1.91–4.91) | 6.00E-06 | |
| Methionine* | 2.94 (1.90–4.81) | 5.00E-06 | |
| Glutamine* | 2.87 (1.84–4.71) | 1.00E-05 | |
| Valine* | 2.84 (1.86–4.57) | 5.00E-06 | |
| Tryptophan* | 2.83 (1.85–4.54) | 5.00E-06 | |
| Sarcosine* | 2.62 (1.64–4.47) | 2.00E-04 | |
| Proline | 2.40 (1.57–3.81) | 1.00E-04 | |
| Tyrosine* | 2.32 (1.56–3.59) | 7.00E-05 | |
| Serine* | 2.13 (1.45–3.27) | 3.00E-04 | |
| Glycine* | 2.04 (1.39–3.09) | 4.00E-04 | |
| Phenylalanine | 1.90 (1.28–2.92) | 2.00E-03 | |
| Ornithine | 1.89 (1.28–2.94) | 3.00E-03 | |
| lysoPC a C16:1* | 1.79 (1.24–2.65) | 2.00E-03 | |
| Low Concentrations in the Normal HbA1c Group | PC ae C36:2 | 0.54 (0.36–0.78) | 2.00E-03 |
| C4 | 0.54 (0.34–0.81) | 6.00E-03 | |
| PC ae C36:1* | 0.53 (0.35–0.79) | 2.00E-03 | |
| PC aa C26:0* | 0.46 (0.28–0.72) | 1.00E-03 | |
| PC aa C34:2* | 0.44 (0.28–0.68) | 3.00E-04 | |
| Hexose* | 0.24 (0.08–0.55) | 5.00E-03 |
*Selected metabolites in both the discovery and replication sets