Table 2.
Effects of treatments on outcome measurements
| Variable | Mean (±SD) | Treatment Effect | Effect of Baseline | ||||||
|---|---|---|---|---|---|---|---|---|---|
| NAC/ Placebo | Time 0 (Baseline) | Week 12 (Endpoint) | Wald | df | P | Wald | df | P | |
| Cigarettes | Placebo | 19.6 (9.7) | 16.4 (11.7) | 9.52 | 1 | 0.002 | 43.03 | 1 | <0.001 |
| NAC | 20.3 (9.8) | 9.4 (10.1) | |||||||
| COexh | Placebo | 16.6 (5.8) | 15.1 (7.6) | 9.92 | 1 | 13.96 | 1 | ||
| NAC | 20.8 (7.6) | 10.4 (8.3) | 0.002 | <0.001 | |||||
| HAM-D | Placebo | 13.6 (4.4) | 12.1 (4.6) | 5.62 | 1 | 17.75 | 1 | ||
| NAC | 12.7 (7.1) | 7.2 (6.3) | 0.018 | <0.001 | |||||
| BMI | Placebo | 26.2 (6.6) | 26.4 (6.9) | 3.98 | 1 | 0.046 | 916.52 | 1 | <0.001 |
| NAC | 27.1 (5.0) | 26.5 (5.3) | |||||||
| SBP | Placebo | 121.4 (23.4) | 118.9 (15.3) | 0.18 | 1 | 0.893 | 4.42 | 1 | 0.035 |
| NAC | 128.2 (16.7) | 121.8 (13.3) | |||||||
| DBP | Placebo | 75.7 (12.7) | 77.1 (11.1) | 0.35 | 1 | 0.554 | 2.67 | 1 | 0.102 |
| NAC | 75.5 (8.2) | 79.1 (5.4) | |||||||
| Sheehan (Social) | Placebo | 3.7 (3.1) | 2.6 (3.6) | 0.28 | 1 | 0.594 | 9.62 | 1 | 0.002 |
| NAC | 1.6 (2.5) | 1.0 (2.0) | |||||||
| Sheehan (Work) | Placebo | 2.6 (3.2) | 2.7 (3.9) | 2.85 | 1 | 0.092 | 88.97 | 1 | <0.001 |
| NAC | 1.7 (2.5) | 0.9 (2.1) | |||||||
| Sheehan (Family) | Placebo | 4.0 (3.7) | 2.9 (3.0 | 2.66 | 1 | 0.103 | 56.21 | 1 | <0.001 |
| NAC | 1.7 (2.5) | 0.6 (1.5) | |||||||