Table 2. Oxidative stress and inflammatory markers.
| Characteristic | Control group | Q1 | Q2 | Q3 | Q 4,5 | P value |
|---|---|---|---|---|---|---|
| GSH (μmol/l) | 1760.2 ± 729 | 2267.8 ± 673* | 1787.5 ± 791 | 1804.8 ± 1013 | 1632.2 ± 612* | <0.001 |
| GSSG (μmol/l) | 286.4 ± 266 | 266.6 ± 110 | 275.5 ± 281 | 241.9 ± 100 | 352.4 ± 211 | ns |
| GSH:GSSG ratio | 5.8 ± 6 | 8.1 ± 4* | 8.3 ± 10 | 7.4 ± 7 | 5.1 ± 5* | <0.05 |
| 8OHDG (pg/mL) | 511.9 ± 264 | 612.5 ± 429* | 647.6 ± 548 | 668.4 ± 398 | 865.2 ± 512* | <0.05 |
| IL-1β (pg/mL) | 2.85 ± 5 | 2.48 ± 1.5* | 3.41 ± 11.7 | 2.75 ± 10.6 | 3.56 ± 8.5* | <0.05 |
| IL-6 (pg/mL) | 19.19 ± 21.9 | 19.43 ± 24.2 | 15.76 ± 16.5 | 19.96 ± 29.3 | 15.72 ± 29.7 | ns |
| IL-10 (pg/mL) | 19.95 ± 21.1 | 19.95 ± 115.8 | 15.97 ± 28.1 | 17.45 ± 27.5 | 18.51 ± 25.1 | ns |
| MCP-1 (pg/mL) | 196.95 ± 65.8 | 189.08 ± 140.6 | 215.60 ± 102.3 | 189.02 ± 112 | 192.4 ± 139 | ns |
| IGF-1 (pg/mL) | 295.58 ± 541.6 | 255.19 ± 381.7 | 347.51 ± 447.4 | 307.38 ± 614.5 | 205.12 ± 362.1 | ns |
| CRP (mg/l) | 1.0 ± 2 | 1.0 ± 1.9 | 1.0 ± 1.6 | 1.9 ± 2.2 | 1.8 ± 2.2 | ns |
Median ± IQR, Q, Quintile; ns, not significant; GSH, glutathione; GSSG, glutathione disulphide; 8OHdG, 8-hydroxy-20-deoxyguanosine; IL-1β, interleukin 1 beta; IL-6, interleukin 6; IL-10, interleukin 10; MCP-1, monocyte chemo-attractant protein -1; IGF-1, insulin like growth factor – 1; CRP, C reactive protein.
*Statistical significance between Q1 and Q 4,5.