Table 2.
Effect of VA on TBARS, LOOH, and CD in plasma and tissues in control and l-NAME- induced hypertensive rats
Parameters | Control | Control + VA (100 mg/ kg Bw) | l-NAME (40 mg/kg Bw) | l-NAME + VA (25 mg/kg Bw) | l-NAME + VA (50 mg/kg Bw) | l-NAME + VA 100 mg/ kg Bw) | |
---|---|---|---|---|---|---|---|
Thiobarbituric acid reactive substances (mmoles/100 g wet tissue) | Plasma (mmol/dl) | 0.15 ± 0.01a | 0.14 ± 0.02a | 0.45 ± 0.46b | 0.38 ± 0.15c | 0.17 ± 0.22a | 0.30 ± 0.02d |
Aorta | 0.42 ± 0.04a | 0.40 ± 0.03a | 1.92 ± 0.12b | 1.36 ± 0.12c | 0.77 ± 0.55d | 1.11 ± 0.83e | |
Kidney | 1.42 ± 0.12a | 1.35 ± 0.12a | 4.22 ± 0.11b | 3.42 ± 0.17c | 1.45 ± 0.15a | 2.72 ± 0.11d | |
Heart | 0.52 ± 0.08a | 0.45 ± 0.13a | 3.17 ± 0.22b | 2.62 ± 0.18c | 0.65 ± 0.15a | 1.55 ± 0.15d | |
Lipid hydroperoxides (mmoles/100 g wet tissue) | Plasma (mmol/dl) | 8.92 ± 0.31a | 8.75 ± 0.19a | 21.48 ± 1.32b | 18.57 ± 1.08c | 10.41 ± 0.52a | 15.53 ± 1.11d |
Aorta | 75.79 ± 5.65a | 73.21 ± 4.37a | 117.85 ± 8.65b | 108.09 ± 6.76c | 86.90 ± 8.35d | 98.80 ± 8.35e | |
Kidney | 63.69 ± 5.72a | 60.71 ± 6.79a | 157.14 ± 9.84b | 148.21 ± 6.68c | 77.19 ± 4.8d | 117.06 ± 6.55e | |
Heart | 66.07 ± 5.14a | 64.28 ± 3.19a | 129.16 ± 8.23b | 120.80 ± 7.71c | 76.19 ± 4.8d | 105.95 ± 5.85e | |
Conjugated dienes (mmoles/100 g wet tissue) | Plasma (mmol/dl) | 0.63 ± 0.03a | 0.62 ± 0.36a | 1.68 ± 0.04b | 0.99 ± 0.12c | 0.83 ± 0.13d | 0.96 ± 0.14e |
Aorta | 39.87 ± 2.31a | 38.12 ± 2.62a | 63.96 ± 4.65b | 59.40 ± 3.77c | 46.27 ± 3.92d | 52.62 ± 4.39e | |
Kidney | 20.3 ± 2.56a | 19.25 ± 1.82a | 42.41 ± 1.91b | 34.86 ± 3.50c | 25.87 ± 6.68d | 28.80 ± 1.18e | |
Heart | 42.07 ± 2.72a | 41.77 ± 3.67a | 68.85 ± 4.83b | 60.65 ± 2.22c | 49.62 ± 4.44d | 54.77 ± 4.63e |
Values are mean ± SD of six rats from each group.
Values not sharing a common superscript differ significantly at P < 0.05 (DMRT).