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. 2019 Oct 28;15(10):e1008086. doi: 10.1371/journal.ppat.1008086

Fig 1. Phylogenetic analysis of UCH37 sequences reveals clustering based on Nedd8 activity.

Fig 1

A) A dendrogram showing the relative similarity of selected UCH37 enzyme sequences. UCHL3 enzymes with known Nedd8 and Ub specificity are also included for reference. All enzymes with experimentally confirmed Nedd8 activity are colored, with Nedd8-active enzymes highlighted in red and inactive ones in blue. B) A multiple alignment of all highlighted enzymes reveals 2 residues (marked with red arrows) whose identity segregates based on Nedd8 activity.