Table 2.
Groups | 1 week | 2 weeks | 8 weeks* |
---|---|---|---|
Reduced glutathione (μmol/g tissue) | |||
Control | 6.52 ± 0.02 | 6.49 ± 0.16 | 6.31 ± 0.08 |
10 mg/kg | 6.00 ± 0.20 | 6.15 ± 0.06 | 5.08 ± 0.06** |
15 mg/kg | 5.80 ± 0.09** | 5.75 ± 0.13** | 5.37 ± 0.07** |
30 mg/kg | 5.71 ± 0.02** | 5.62 ± 0.18** | 4.18 ± 0.09** |
Catalase (μmol H2O2 consumed/min/mg protein) | |||
Control | 0.21 ± 0.03 | 0.23 ± 0.03 | 0.57 ± 0.27 |
10 mg/kg | 0.16 ± 0.02 | 0.21 ± 0.03 | 0.56 ± 0.03 |
15 mg/kg | 0.13 ± 0.02 | 0.19 ± 0.03 | 0.48 ± 0.36 |
30 mg/kg | 0.12 ± 0.03 | 0.17 ± 0.02 | 0.38 ± 0.03** |
Lipid peroxidation (nmol MDA formed/g tissue) | |||
Control | 2.37 ± 0.19 | 2.17 ± 0.16 | 2.03 ± 0.04 |
10 mg/kg | 2.88 ± 0.11 | 3.49 ± 0.16** | 4.17 ± 0.08** |
15 mg/kg | 2.57 ± 0.16 | 4.12 ± 0.19** | 4.83 ± 0.13** |
30 mg/kg | 3.15 ± 0.21 | 5.02 ± 0.19** | 6.14 ± 0.04** |
Results are expressed as mean ± SEM (n = 6).
* Significant (P < 0.05) increase or decrease of DZN time-dependent toxicity effect when compared to the one week exposure group.
** Significant (P < 0.05) increase or decrease of DZN dose-dependent toxicity effect when compared to the control.