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Potential noninvasive diagnostic biomarkers of hepatic oxidative stress in NAFLD/NASH
| Products of oxidative stress, which is parallel to increase of ROS |
| Malondialdehyde |
| 4-Hydroxy-2-nonenal |
| F2-isoprostanes |
| 3-Nitrotyrosine |
| 8-Hydroxy-2′deoxyguanosine |
| Xanthine oxidase |
| CYP450 enzyme isoforms (CYP2E1 and CYP4A) |
| Enzymatic anti-oxidants: SOD, GPx, Catalase, and GSH reductase |
| Non-enzymatic anti-oxidants: GSH, thioredoxin, ferritin, bilirubin, uric acid, and vitamins (e.g. E, C) |
