Table 4.
Activities of phase I detoxification enzymes in the liver of control and experimental hamsters
| Liver | Buccal mucosa | ||||
|---|---|---|---|---|---|
| Groups | Treatment/parameters | Cytochrome P450 (UX /mg protein) | Cytochrome b5 (UY/mg protein) | Cytochrome P450 (UX /mg protein) | Cytochrome b5 (UY/mg protein) |
| 1. | DMBA | 1.70 ± 0.12a | 1.98 ± 0.18a | 3.50 ± 0.28a | 0.76 ± 0.06a |
| 2. | DMBA + geraniol (250 mg/kg b.w.) | 0.76 ± 0.06b | 1.08 ± 0.16b | 2.00 ± 0.20b | 0.42 ± 0.04b |
| 3. | Geraniol alone (250 mg/kg b.w.) | 0.69 ± 0.04c | 0.98 ± 0.08c | 1.84 ± 0.16c | 0.40 ± 0.04c |
| 4. | Corn oil + liquid paraffin control | 0.66 ± 0.04c | 0.92 ± 0.06c | 1.80 ± 0.14c | 0.38 ± 0.03c |
| 5. | Control | 0.68 ± 0.04c | 0.94 ± 0.08c | 1.78 ± 0.14c | 0.34 ± 0.02c |
Values are expressed as mean ± SD for 10 hamsters in each group.
a–cValues not sharing a common superscript letter (a, b, and c) differ significantly at P < 0.05 (DMRT).
X – micromoles of cytochrome P450.
Y – micromoles of cytochrome b5.