Table 3. Targeted lesion – logistic regression analyses.
| Odds Ratio | P | 95% CI | ||
|---|---|---|---|---|
|
|
||||
| PI-RADS v2 alone | ||||
| PI-RADS v2 | ||||
| 4 | 3.41 | <0.001 | 1.92 | 6.08 |
| 5 | 16.80 | <0.001 | 9.24 | 30.55 |
|
| ||||
| AUROC = 0.74 (95% CI = 0.70-0.77) | ||||
|
| ||||
| PI-RADS v2 and ADC | ||||
|
| ||||
| PI-RADS v2 | ||||
| 4 | 2.18 | 0.01 | 1.18 | 4.04 |
| 5 | 6.91 | <0.001 | 3.69 | 12.93 |
| ADC | 0.996 | <0.001 | 0.995 | 0.997 |
|
| ||||
| AUROC = 0.82 (95% CI = 0.78-0.85) | ||||
|
|
||||
| PI-RADS v2 and ADC categories | ||||
|
| ||||
| PI-RADS v2 | ||||
| 4 | 2.22 | 0.01 | 1.21 | 4.08 |
| 5 | 6.99 | <0.001 | 3.75 | 13.05 |
| ADC categories | ||||
| 2 | 2.00 | 0.025 | 1.09 | 3.67 |
| 3 | 4.40 | <0.001 | 2.49 | 7.79 |
| 4 | 10.59 | <0.001 | 5.85 | 19.17 |
|
| ||||
| AUROC = 0.81 (95% CI = 0.77-0.85) | ||||
|
|
||||
| PI-RADS v2 and PSAD categories | ||||
|
| ||||
| PI-RADS v2 | ||||
| 4 | 3.47 | <0.001 | 1.92 | 6.25 |
| 5 | 15.02 | <0.001 | 8.14 | 27.73 |
| PSAD categories | ||||
| 2 | 2.59 | <0.001 | 1.54 | 4.36 |
| 3 | 2.86 | <0.001 | 1.65 | 4.98 |
| 4 | 4.59 | <0.001 | 2.76 | 7.61 |
| AUROC = 0.79 (95% CI = 0.74-0.82) | ||||
| PI-RADS v2 and PSAD | ||||
| PI-RADS v2 | ||||
| 4 | 3.47 | <0.001 | 1.89 | 6.38 |
| 5 | 14.89 | <0.001 | 7.88 | 28.12 |
| PSAD | 434.39 | <0.001 | 52.47 | 3596.55 |
|
| ||||
| AUROC = 0.80 (95% CI = 0.75-0.82) | ||||
|
|
||||
| PI-RADS v2 and PSADtz | ||||
|
| ||||
| PI-RADS v2 | ||||
| 4 | 3.37 | <0.001 | 1.80 | 6.31 |
| 5 | 15.18 | <0.001 | 7.94 | 29.04 |
| PSAD transition zone | 3.44 | <0.001 | 1.88 | 6.32 |
| AUROC = 0.80 (95% CI = 0.76-0.83) | ||||
| PI-RADS v2, PSAD categories, and ADC categories | ||||
| PI-RADS v2 | ||||
| 4 | 2.25 | 0.008 | 1.23 | 4.11 |
| 5 | 6.58 | <0.001 | 3.52 | 12.31 |
| PSAD categories | ||||
| 2 | 2.48 | 0.002 | 1.40 | 4.39 |
| 3 | 2.22 | 0.009 | 1.22 | 4.04 |
| 4 | 3.67 | <0.001 | 2.21 | 6.10 |
| ADC categories | ||||
| 2 | 1.77 | 0.07 | 0.95 | 3.29 |
| 3 | 3.67 | <0.001 | 2.07 | 6.52 |
| 4 | 8.78 | <0.001 | 4.76 | 16.20 |
|
| ||||
| AUROC = 0.83 (95% CI = 0.79-0.86) | ||||
|
| ||||
| PI-RADS v2, PSAD categories, ADC categories, age, and palpable nodule | ||||
|
| ||||
| Age | 1.03 | 0.031 | 1.00 | 1.06 |
| Palpable Nodule | 2.46 | 0.006 | 1.30 | 4.69 |
| PI-RADS v2 | ||||
| 4 | 2.16 | 0.012 | 1.18 | 3.95 |
| 5 | 6.18 | <0.001 | 3.30 | 11.58 |
| PSAD categories | ||||
| 2 | 2.46 | 0.003 | 1.36 | 4.46 |
| 3 | 2.21 | 0.01 | 1.20 | 4.07 |
| 4 | 3.75 | <0.001 | 2.25 | 6.25 |
| ADC categories | ||||
| 2 | 1.76 | 0.07 | 0.95 | 3.23 |
| 3 | 3.46 | <0.001 | 1.96 | 6.13 |
| 4 | 7.73 | <0.001 | 4.18 | 14.3 |
| AUROC = 0.84 (95% CI = 0.81-0.87) | ||||
P = probability; CI = confidence interval; PI-RADS v2 = Prostate Imaging Reporting and Data System, version 2; AUROC = area under the receiver-operating characteristic curve; PSAD = prostate-specific antigen density; tz = transition zone; ADC = apparent diffusion coefficient