Table 2. Effects of edaravone on the activities of reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GR) in the cardiac tissue of experimental groups.

Experimental groups	GSH (µmol GSH/mg prot)	GST (nmol NADPH/minute/mg prot)	GPx (nmol CDNB/minute/mg prot)	GR (nmol NADPH/minute/mg prot)
Normal control	1.33 ± 0.12	8.11 ± 0.29	5.83 ± 0.32	6.53 ± 0.32
Edaravone per se (10 mg/kg)	1.09 ± 0.13	7.04 ± 0.46	5.38 ± 0.39	5.21 ± 0.82
Isoproterenol (85 mg/kg)	0.23 ± 0.19†	2.10 ± 0.24†	1.67 ± 0.28†	1.58 ± 0.15†
Edaravone (1 mg/kg) + ISO	0.63 ± 0.07*	3.81 ± 0.53*	2.73 ± 0.19*	2.98 ± 0.17
Edaravone (3 mg/kg) + ISO	0.98 ± 0.05**	4.19 ± 0.48**	3.32 ± 0.20**	3.38 ± 0.35*
Edaravone (10 mg/kg) + ISO	1.02 ± 0.09**‡	4.72 ± 0.33**	3.51 ± 0.18**	3.73 ± 0.41**

Each value is mean ± SEM for six rats in each group.

*P < 0.05 vs. ISO toxic group.

**P < 0.01 vs. ISO toxic group.

^†P < 0.01 vs. normal control.

^‡P < 0.05 vs. edaravone (1 mg/kg) + ISO.