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. 2014 Nov 8;20(3):116–125. doi: 10.1179/1351000214Y.0000000113

Figure 3.

Figure 3.

Capsaicin- and capsaicin epoxide-induced decrease in metabolic activity. The capsaicin and capsaicin epoxide cytotoxicities were estimated by measuring the ability of live cells to metabolize 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to formazan. HDFs, human dermal fibroblasts; NIH3T3, mouse embryonic fibroblasts; DU145, human prostate carcinoma cells; A549, human lung carcinoma cells; MCF7, human breast carcinoma cells; HeLa, human cervical carcinoma cells; ACHN, human renal carcinoma cells. The bars indicate the SD (n = 5). *P < 0.05 and ***P < 0.001 compared with the control conditions (24-hour treatment with capsaicin versus the control conditions); ###P < 0.001 compared with the control conditions (24-hour treatment with capsaicin epoxide versus the control conditions); +P < 0.05 and +++P < 0.001 compared with 24-hour treatment with capsaicin (24-hour treatment with capsaicin versus 24-hour treatment with capsaicin epoxide) (ANOVA and Tukey's a posteriori test).