Table 2. Effect of sodium nitrite (80 mg/kg/day) alone and its combination with NSO (2.5, 5, and 10 ml/kg/day) for 12 weeks on levels of MDA and superoxide anion (mean ± SE).
| Control | Control + Nigella oil (5 ml/kg) | Control + Nigella oil (10 ml/kg) | Sodium nitrite (80 mg/kg) | Sodium nitrite + Nigella oil (2.5 ml/kg) | Sodium nitrite + Nigella oil (5 ml/kg) | Sodium nitrite + Nigella oil (10 ml/kg) | |
|---|---|---|---|---|---|---|---|
| Serum MDA (nM) | 158.3 ± 11.5 | 148.7 ± 12.2 | 151.6 ± 13.7 | 389.5 ± 28.2* | 311.2 ± 19.6*# | 227.6 ± 21.1*#$ | 171.5 ± 16.1#$% |
| Serum superoxide anion (µM) | 45.2 ± 4.11 | 48.8 ± 3.81 | 44.64 ± 3.94 | 91.4 ± 5.32* | 79.5 ± 4.73*# | 64.8 ± 4.25*#$ | 51.7 ± 3.9#$% |
| Renal MDA (nmol/g protein) | 131.6 ± 8.46 | 139.2 ± 10.6 | 142.9 ± 12.3 | 456.4 ± 37.1* | 379.6 ± 31.2*# | 235.3 ± 19.3*#$ | 197 ± 17.1*#$% |
| Renal superoxide anion (µmol/g protein) | 39.32 ± 3.11 | 36.74 ± 2.91 | 41.83 ± 4.12 | 82.54 ± 6.73* | 76.45 ± 6.45* | 62.17 ± 4.78*#$ | 43.4 ± 4.1#$% |
*Significant difference when compared with the control groups at P < 0.05.
#Significant difference when compared with sodium nitrite groups at P < 0.05.
$Significant difference when compared with Nigella oil (2.5 ml/kg) group at P < 0.05.
%Significant difference when compared with Nigella oil (5 ml/kg) group at P < 0.05.