Table 3. Effect of sodium nitrite (80 mg/kg/day) alone and its combination with NSO (2.5, 5, and 10 ml/kg/day) for 12 weeks on levels of reduced glutathione and superoxide dismutase (SOD) (mean ± SE).
| Control | Control + Nigella oil (5 ml/kg) | Control + Nigella oil (10 ml/kg) | Sodium nitrite (80 mg/kg) | Sodium nitrite + Nigella oil (2.5 ml/kg) | Sodium nitrite + Nigella oil (5 ml/kg) | Sodium nitrite + Nigella oil (10 ml/kg) | |
|---|---|---|---|---|---|---|---|
| Blood glutathione (mM) | 8.93 ± 0.74 | 8.23 ± 0.81 | 9.14 ± 0.89 | 4.32 ± 0.26* | 5.11 ± 0.43* | 7.43 ± 0.54#$ | 7.79 ± 0.67#$ |
| Serum SOD (U/l) | 34.64 ± 2.94 | 33.23 ± 2.62 | 34.41 ± 3.12 | 17.41 ± 1.63* | 22.71 ± 2.11* | 27.71 ± 2.31*#$ | 31.8 ± 2.78#$ |
| Renal glutathione (mmol/g protein) | 11.21 ± 1.04 | 11.64 ± 1.12 | 12.53 ± 1.22 | 7.91 ± 0.63* | 8.83 ± 0.73* | 9.64 ± 0.73*# | 10.9 ± 1.1#$ |
| Renal SOD (U/g protein) | 27.32 ± 2.12 | 26.89 ± 1.94 | 27.87 ± 2.32 | 19.84 ± 1.48* | 22.21 ± 2.18* | 25.93 ± 1.97$ | 26.7 ± 2.1#$ |
*Significant difference when compared with the control groups at P < 0.05.
#Significant difference when compared with sodium nitrite groups at P < 0.05.
$Significant difference when compared with Nigella oil (2.5 ml/kg) group at P < 0.05.
%Significant difference when compared with Nigella oil (5 ml/kg) group at P < 0.05.