Table 1. Effects of long-term berberine administration on serum ALT, AST, ALP, albumin, and body weight (BW) in different animal groups at the end of the treatment period (n = 7).
| Parameters | Control | Lead | Lead + berberine | Lead + silymarin | Control + berberine |
|---|---|---|---|---|---|
| ALT (U/l) | 74.28 ± 1.51 | 132 ± 7.02*** | 89.71 ± 0.35 | 81.71 ± 3.14 | 70.7 ± 3.48 |
| AST (U/l) | 155.71 ± 3.19 | 197.42 ± 6.04*** | 165.28 ± 8.71 | 159 ± 7.33 | 160.14 ± 5.24 |
| ALP (U/l) | 129.85 ± 3.23 | 191.14 ± 2.39*** | 141.85 ± 1.83 | 135.42 ± 2.54 | 132.71 ± 7.41 |
| Albumin (g/dl) | 3.04 ± 0.14 | 2.34 ± 0.09*** | 2.87 ± 0.04 | 2.91 ± 0.03 | 3.12 ± 0.10 |
| BW (g) | 311 ± 5.7 | 213 ± 9.1*** | 286 ± 2.5 | 292 ± 5 | 331 ± 10 |
The data are represented as mean ± SEM.
Asterisk indicates significant difference compared to control group (***P < 0.001, ANOVA, Tukey's test for post hoc comparisons).