VC-IV modulated CDDP-induced alterations of renal redox status in mice. VC-IV reduced (a) ROS level, (b) NO level, (c) LPO level, (d) GSSG level and enhanced (e) GSH level, (f) SOD activity, (g) CAT activity, (h) GPx activity, (i) GST activity in the kidneys of mice. Data were represented as mean ± S.D. asignificantly (P < 0.05) different from vehicle-treated group, bsignificantly (P < 0.05) different from VC-IV-treated group, csignificantly (P < 0.05) different from CDDP-treated group, dsignificantly (P < 0.05) different from CDDP + LCME-treated group, and esignificantly (P < 0.05) different from CDDP + VC-IV concomitant-treatment group.