Table 1. Renal functional index in mice serum of different treatment groups.
| Groups | Creatinine (mg/dl) | BUN (mg/dl) | Na+ (mM/l) | K+ (mM/l) | Cl– (mM/l) |
|---|---|---|---|---|---|
| Vehicle | 0.49 ± 0.04 | 20.99 ± 1.63 | 141.86 ± 18.21 | 4.16 ± 0.45 | 101.29 ± 4.54 |
| VC-IV | 0.48 ± 0.03 | 20.82 ± 0.78 | 142.49 ± 11.96 | 4.49 ± 0.57 | 106.16 ± 3.85 |
| CDDP | 2.45 ± 0.16ab | 44.85 ± 3.57ab | 139.13 ± 6.34 | 4.47 ± 0.41 | 103.54 ± 7.85 |
| CDDP + LCME | 2.33 ± 0.15ab | 44.35 ± 4.04ab | 146.02 ± 5.79 | 4.35 ± 0.42 | 101.87 ± 5.48 |
| CDDP + VC-IV Con | 1.34 ± 0.12abcd | 30.32 ± 2.38abcd | 143.32 ± 5.16 | 4.34 ± 0.49 | 107.38 ± 11.06 |
| CDDP + VC-IV Pre | 1.07 ± 0.09abcde | 27.84 ± 1.81abcd | 138.17 ± 8.49 | 4.33 ± 0.53 | 103.83 ± 5.42 |
Vehicle: vehicle-treated group; VC-IV: only VC-IV-treated group; CDDP: only CDDP-treated group; CDDP + LCME: CDDP + L-cysteine methyl ester hydrochloride treated group; CDDP + VC-IV Con: CDDP + VC-IV concomitant-treatment group; CDDP + VC-IV Pre: CDDP + VC-IV pre-treatment group. Data were represented as mean ± S.D. asignificantly (P < 0.05) different from vehicle-treated group, bsignificantly (P < 0.05) different from VC-IV-treated group, csignificantly (P < 0.05) different from CDDP-treated group, dsignificantly (P < 0.05) different from CDDP + LCME-treated group and esignificantly (P < 0.05) different from CDDP + VC-IV concomitant-treatment group.