Table 2. Effect of VC-IV administration on morphological changes as assessed by histopathological analysis of kidneys of mice treated with CDDP.
| Pathological changes | Groups | |||||
|---|---|---|---|---|---|---|
| Vehicle | VC-IV | CDDP | CDDP + LCME | CDDP + VC-IV Con | CDDP + VC-IV Pre | |
| Interstitial hemorrhage | – | – | +++ | +++ | + | + |
| Glomerular atrophy | – | – | +++ | ++ | +/– | – |
| Tubular brush border loss | – | – | +++ | +++ | ++ | + |
| Tubular atrophy | – | – | ++ | ++ | + | – |
| Cell infiltration | – | – | +++ | +++ | ++ | +/– |
| Cell death (TUNEL) | – | – | +++ | +++ | +/– | – |
Vehicle: vehicle-treated group; VC-IV: only VC-IV-treated group; CDDP: only CDDP-treated group; CDDP + LCME: CDDP + L-cysteine methyl ester hydrochloride-treated group; CDDP + VC-IV Con: CDDP + VC-IV concomitant-treatment group; CDDP + VC-IV Pre: CDDP + VC-IV pre-treatment group. −: none; +: mild damage; ++: moderate damage; and +++: severe damage are semiquantitative scores by a pathologist unaware of the type of treatment.