Table 2:
Diagnostic performance metrics of Amino Acid Dysregulation Metabotypes (AADM). Each AADM consists of three ratios with a different branched chain amino acid (BCAA) in the denominator. Abbreviations: Pos., positive, Pred., predictive; Train, training set; Test, test set; Hyp, 4-Hydroxyproline; Hse, Homoserine; Orn, Ornithine.
| AADM Diagnostic |
Sensitivity | Specificity | Pos. Pred. Value | |||
|---|---|---|---|---|---|---|
| Train | Test | Train | Test | Train | Test | |
| Ala:BCAA | 0.150 | 0.141 | 0.929 | 0.937 | 0.864 | 0.881 |
| Gln:BCAAa | 0.079 | 0.080 | 0.988 | 1.000 | 0.952 | 1.000 |
| Gly:BCAAa | 0.095 | 0.099 | 0.988 | 0.975 | 0.960 | 0.929 |
| Hse:BCAA | 0.036 | 0.080 | 0.988 | 1.000 | 0.900 | 1.000 |
| Orn:BCAAa | 0.079 | 0.103 | 0.976 | 0.975 | 0.909 | 0.931 |
| Ser:BCAA | 0.091 | 0.106 | 0.965 | 0.949 | 0.885 | 0.875 |
| Hyp:BCAA | 0.087 | 0.080 | 0.965 | 0.924 | 0.880 | 0.778 |
a
AADMs are a reproducible metabotype that is identified across training and test populations with a sensitivity greater than 5% and a positive predictive value greater than 90%.