Comparison 1. 30 ug ethinyl estradiol and 150 ug levonorgestrel, 28‐day versus 91‐day cycles for one year.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Overall Discontinuation	1	682	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.66 [1.19, 2.31]
1.2 Discontinuation for bleeding reasons	1	682	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.99 [1.50, 5.93]
1.3 Pregnancy	1	682	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.64 [0.13, 3.12]
1.4 Overall adherence based on self reported diary	1	682	Odds Ratio (M‐H, Fixed, 95% CI)	0.68 [0.34, 1.34]
1.5 Symptoms: Headache	1	682	Odds Ratio (M‐H, Fixed, 95% CI)	0.69 [0.48, 1.00]
1.6 Mean total bleeding days (bleeding + spotting) for entire study period (364 days)	1	664	Mean Difference (IV, Fixed, 95% CI)	‐2.60 [‐8.03, 2.83]
1.7 Mean bleeding days only for entire study period (364 days)	1	664	Mean Difference (IV, Fixed, 95% CI)	‐14.30 [‐17.65, ‐10.95]