Comparison 3. 50 ug ethinyl estradiol and 250 ug levonorgestrel, 28‐days versus 1 year cycles for one year, dosed vaginally.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Overall discontinuation	1	900	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.02 [0.70, 1.49]
3.2 Discontinuation for bleeding reasons	1	900	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.27 [0.34, 4.73]
3.3 Pregnancy	1	900	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.14 [0.02, 0.97]
3.4 Mean of total bleeding days (bleeding + spotting) in first trimester (90 days)	1	722	Mean Difference (IV, Fixed, 95% CI)	‐10.66 [‐11.28, ‐10.04]
3.5 Mean of total bleeding days (bleeding + spotting) in second trimester (90 days)	1	670	Mean Difference (IV, Fixed, 95% CI)	‐11.79 [‐12.44, ‐11.14]
3.6 Mean of total bleeding days (bleeding + spotting) in third trimester (90 days)	1	606	Mean Difference (IV, Fixed, 95% CI)	‐12.43 [‐12.86, ‐12.00]
3.7 Mean of total bleeding days (bleeding + spotting) in fourth trimester (90 days)	1	339	Mean Difference (IV, Fixed, 95% CI)	‐11.86 [‐12.46, ‐11.26]