Table 1.
Minimum Inhibitory Concentrations and Half Maximal Inhibitory Concentrations for Berberine (Compound 1) and Magnolol (Compound 2) Alone and in Combination with Spiked A. keiskei Extract. The MICs of Berberine and Magnolol in Isolation are Consistent with Previous Reports.9,37
| Treatment | MIC (μg/mL) | IC50 (μg/mL) | FIC index a |
|---|---|---|---|
| berberine (1) | 75 | 29.5 | -- |
| berberine (1) + spiked A. keiskei extract b | 150 | 85 | 3 |
| magnolol (2) | 6.25 | 4.1 | -- |
| magnolol (2) + spiked A. keiskei extract b | 25 | 8.9 | 5 |
| spiked A. keiskei extract | >100 μg/mL | >100 μg/mL | -- |
a
ΣFICs were calculated using the following equation: ΣFIC = FICA + FICB = ([A]/ MICA) + ([B]/MICB), where A and B are the compounds/extracts tested in combination, MICA is the minimum inhibitory concentration of A alone, MICB is the minimum inhibitory concentration of B alone, [A] is the MIC of A in the presence of B, and [B] is the MIC of B in the presence of A.
b
values expressed for magnolol and berberine’s MIC/IC50 in combination with 100 μg/mL spiked extract.