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. 2019 Nov 1;10:2491. doi: 10.3389/fmicb.2019.02491

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Copyright © 2019 Gu, Deng, Ren, Zhao, Yu, Guo, Dai, Chen, Li, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG pathway analysis of DEGs following H1N1 infection revealed significant pathways (padj < 0.05) involved in local immune responses and cell adhesion molecules in the lung of mice on (A,B) 7 and (C,D) 28 dpi. (A) The enrichment pathways of up-regulated genes at 7 dpi; (B) the enrichment pathways of the down-regulated genes at 7 dpi; (C) the enrichment pathways of up-regulated genes at 28 dpi; (D) the enrichment pathways of down-regulated genes at 28 dpi. The size of the circle indicated the number of the genes. The color of the circle indicated Q value. Gene Ratio refers the ratio of Sample number and Background number enriched in the pathway. The value range of adjusted P-value (padj) is [0,1], and the closer to zero, the enrichment is more significant.