Table 1.

Clinical, radiological and biochemical characteristics of the study population

Pat no	Age (year)	Sex	BMI (kg/m2)	Clinical presentation	Hypercortisolism	Main clinical features	Radiological findings	S- cortisol (nmol/L) after ONDST	ACTH (pmol/L)	UFC (times the ULN)	S-cortisol (nmol/L) at midnight	S-cortisol (nmol/L) after LDDST
1	55	F	26.0	Bilateral adrenal incidentaloma	MACS	Muscle weakness Hypertension	Bilateral adenomas: Right 32 × 18 mm	840	1.7	0.8	340	630
							Left 14 × 8 mm
2	60	F	23.9	Bilateral adrenal incidentaloma	MACS	Hypertension Type 2 DM Muscle weakness	Bilateral adenomas: Right 28 × 22 mm	110	1.9	1.0	93	100
							Left 15 × 10 mm
3	54	M	22.4	Bilateral adrenal incidentaloma	MACS	Hypertension Weight gain Decreased libido Impaired memory	Bilateral adenomas: Right 19 × 14 mm	190	3.2	0.8	140	120
							Left 28 × 25 mm
4	61	F	33.0	Bilateral adrenal incidentaloma	MACS	Hypertension Obesity	Multiple adenomas, two in right adrenal and three in left, largest adenomas: Right 32 × 22 mm	563	<0.2	0.6	250	420
							Left 19 × 18 mm
5	62	M	24.1	Bilateral adrenal incidentaloma	MACS	Hypertension Muscle weakness Impaired memory	Bilateral adenomas: Right 23 × 16 mm	120	3,6	0.9	120	120
							Left 34 × 36 mm
6	60	F	30.5	Bilateral adrenal incidentaloma	MACS	Mild Cushingoid features Hypertension Type 2 DM	Bilateral adenomas: Right 23 × 15 mm	150	2.6	0.8	170	120
							Left 10 × 10 mm
7	59	F	34.6	Bilateral adrenal incidentaloma	Moderate CS	Cushingoid features Hypertension Type 2 DM Fatigue Depression	Bilateral adenomas: Right 22 × 15 mm	610	1.1	1.3	420	560
							Left 64 × 50 mm
8	57	M	34.9	Bilateral adrenal incidentaloma	Moderate CS	Cushingoid features Hypertension Osteoporosis Fatigue Depression	Bilaterally enlarged adrenal glands: Right 50 × 47 mm	550	0.9	4.7	570	250
							Left 41 × 32 mm
9	39	F	23.6	CS	Moderate CS	Cushingoid features Depression Amenorrhea Osteoporosis Fatigue	Normal adrenal glands	677	1.3	1.6	560	747
10	11	F	40.8	CS	Severe CS	Cushingoid features Weight gain Decreased growth rate Hypertension	Normal adrenal glands	830	1.7	3.9	680	340
11	51	F	30.1	CS	Severe CS	Cushingoid features Weight gain Hypertension Type 2 DM Fatigue Muscle weakness	Mildly enlarged adrenal glands bilaterally with suspected 9 mm adenoma in the right adrenal gland	730	2.4/4.0/5.7	10.2	900	–

F female, M male, AVS adrenal venous sampling, MACS mild autonomous cortisol secretion, BMI body mass index, CS Cushing’s syndrome, ACTH adrenocorticotropic hormone at 8 a.m. (ref. 2.0–11 pmol/L), UFC 24-h urinary free cortisol, ULN upper limit of the normal range, ONDST 1 mg overnight dexamethasone suppression test, LDDST low-dose dexamethasone suppression test, DM diabetes mellitus type 2