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. 2019 Nov 7;9:16168. doi: 10.1038/s41598-019-52507-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The relative content of ALDH2 mRNA in BT-474 cells treated with HER2-specific monoclonal antibodies as shown by qRT-PCR analysis. The effect of 1 or 10 μg/ml of TPB, PPB, PHC/TLC or T/P-biVLC antibodies compared to the control – cells treated with 1 or 10 μg/ml rituximab (Hoffmann-La Roche). Cells were incubated with antibodies for 5 days. The mean values and standard error are given. **p < 0.01; ***p < 0.001 (Mann-Whitney test) for statistical significance of the difference compared to the control.