Table 1.

The affinities of anti-HER2 bi-TPB-PPB antibodies binding to human HER2-ECD.

Antibody	Ka (105 M−1 s−1)	Kd (10−5 s−1)	KD (10−10 M)
Herceptin	5.9 ± 1.8	6.2 ± 1.5	1.73 ± 0.95
Perjeta	16.4 ± 10.6	3.7 ± 1.38	0.329 ± 0.24
TPB	21.0 ± 11.0	5.7 ± 1.1	0.17 ± 0.02
PPB	12.2 ± 8.1	4.0 ± 2.1	0.39 ± 0.14
PHC-TLC	33.4 ± 16.0	50.2 ± 7.47	1.81 ± 0.76
T/P-biVLC	18.7 ± 1.1	9.11 ± 1.6	0.50 ± 0.10

Experimental error is the SD from three independent determinations.