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. 2019 Nov 7;10:5076. doi: 10.1038/s41467-019-12846-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Validation of the biomarkers in PDCs and commercial cell lines. a The copy number variations (CNVs) of CDKN2A and CDKN2B were shown in eight ESCC PDCs and their corresponding tumor tissue. b Fifty percent growth inhibitory concentrations (IC50s) of palbociclib and ribociclib (LEE011) in eight ESCC PDCs with CDKN2A or CDKN2B loss or with no CNV of CDKN2A and CDKN2B. c The CNVs of CDKN2A and CDKN2B were illustrated in ten commercial cell lines. d IC50s of palbociclib and ribociclib in ten ESCC commercial cell lines with CDKN2A or CDKN2B loss or with no CNV of CDKN2A and CDKN2B. Error bars correspond to the standard deviation of IC50s. The comparisons between different groups of compound IC50s were performed using Student’s t test