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. 2019 Nov 7;9:16210. doi: 10.1038/s41598-019-52736-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic gene expression profile in NASH and NASH + ISO group compared to CTL group. (a) Volcano plot of DEGs with fold-change over ± 2.0 (green: down-regulated, and red: up-regulated genes) between NASH vs. CTL, and NASH + ISO vs. CTL. (b) Quantitation of number of DEGs. (c) Venn diagram showing the overlap of DEGs between NASH vs. CTL, and NASH + ISO vs. CTL. GO process analysis and KEGG pathway for the up-regulated 257 genes (d) and down-regulated 147 genes (e) from overlapping 404 DEGs with p-value as *p < 0.05, **p < 0.01, ***p < 0.001.