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. 2019 Nov 1;7:294. doi: 10.3389/fbioe.2019.00294

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Copyright © 2019 Mendes-Pinheiro, Anjo, Manadas, Da Silva, Marote, Behie, Teixeira and Salgado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Design of the in vivo experiments. The animals were unilaterally injected with 6-OHDA directly into the MFB. After 3 weeks, animals were behaviorally characterized (through rotarod, staircase and rotameter tests) to validate the model. At week 5, 6-OHDA-lesioned animals received hBMSCs transplants or hBMSCs secretome in the SNpc and striatum. Behavior analysis was performed 1, 4, and 7 weeks after treatments, using the rotarod and staircase tests, and posteriorly sacrificed to proceed with the histological analysis.