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. 2019 Nov 1;10:1140. doi: 10.3389/fneur.2019.01140

Table 3.

Function of synaptic protein targets of amyloid beta oligomers.

Protein name Classification Function References
α3-Na/K-ATPase Neuronal receptor, transport proteins on cell membranes A death target of Alzheimer patient amyloid-beta assembly, regulating neuron membrane potential (49, 56, 63)
synGap Synaptic GTPase activating protein Maintaining signal network of glutamate receptor (60, 64)
Shank3 Scaffold protein of PSD Promoting the formation of excitatory synapses and the development of dendritic spines, maintain the function of glutamate receptors (65, 66)