Table 3.
Function of synaptic protein targets of amyloid beta oligomers.
| Protein name | Classification | Function | References |
|---|---|---|---|
| α3-Na/K-ATPase | Neuronal receptor, transport proteins on cell membranes | A death target of Alzheimer patient amyloid-beta assembly, regulating neuron membrane potential | (49, 56, 63) |
| synGap | Synaptic GTPase activating protein | Maintaining signal network of glutamate receptor | (60, 64) |
| Shank3 | Scaffold protein of PSD | Promoting the formation of excitatory synapses and the development of dendritic spines, maintain the function of glutamate receptors | (65, 66) |