Fig. 6.

Effect of HST on DSS-induced dysbiosis. (a) Alpha-diversity in stool samples as measured by the Chao1 indexes in a longitudinal setting. Alpha-diversity in stool (b) and colon (c) samples as measured by the Chao1 indexes on the day of animal sacrifice. There was a significant reduction in faecal microbiome diversity only in group d-DSS compared to control group C—HST1 (n = 5–8 per group, non-parametric test, FDR < 0.1). No significant differences were found in the colonic microbiome (n = 4–6 per group). Correlations between microbiome composition in colonic tissues and clinical manifestations as measured by the Spearman correlation test (P < 0.05). In colon samples, genera were significantly correlated with colon length (d) and with DAI score (e). (f) In stool samples, the evolution of several bacterial genera selected based on their correlation with clinical manifestations are plotted according to the longitudinal setting.