Fig. 2.

Genotype modify responsiveness in cardiac function and functional capacity. A) V- patients had the greatest increase in EF at 12 months compared with VUS. EF decreased in PV+ patients. B) Six-minute walk distance increased in the V− patients vs. VUS and PV+. C) V− patients improved to a greater extent in MLHFQ contrasted with VUS and PV+. D) Percentage change in NYHA shows significant difference between groups. V− improved by 60% in contrast to 53% in VUS and 25% in PV+. E) EPC-cfu significantly increased over time only in V− group. V− = negative for any pathologic variants group (green), VUS = variants of uncertain significance group (orange), PV+ = positive for pathologic/likely pathologic variant group (red). *p = <0.05, **p = 0.01 ***p = 0.001 ****p<0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)