Fig. 2.

Hierarchical clustering based on MRD-associated metabolites and pathways in the combined discovery and replication cohorts identifies two groups of patients with differential rates of MRD positivity. Patients shown in columns and metabolites in rows. Top: horizontal grey bars and cluster dendrogram indicating cluster membership. Right: Shading indicates metabolite abundance in each sample relative to the overall mean; darker colors represent greater relative abundance. Extreme values (>10-fold increase) are suppressed for visualization purposes. Bottom: patient's MRD status, immunophenotype (B: B-lineage; T: T-lineage), cytogenetic findings (F: favourable/neutral; U: unfavourable), NCI risk group (S: standard risk; H: high risk), and ethnicity (H: Hispanic; N: Non-Hispanic).