Fig. 3.

Clustered correlations of IDO1 methylation with signatures of tumor infiltrating immune cells. mRNA expression (RNASeq) signatures described in Thorsson et al. were used to estimate infiltration of distinct immune cell subsets [49]. These signatures were correlated with IDO1 methylation at three CpG sites. Only statistically significant (P < 0.05) Spearman's ρ rank correlation coefficients were used for unsupervised clustering and illustration (n.s.: not significant).