Table 4. In-hospital mortality rates and long-term neurodevelopmental outcomes in VLBW infants who underwent single or multiple surgeries.
Variables | No surgery | Any surgery | 1 time | 2 times | ≥ 3 times | |
---|---|---|---|---|---|---|
No. (%) | 6,376 (80.9) | 1,509 (19.1) | 1,162 (14.7) | 280 (3.6) | 67 (0.9) | |
Mortality during NICU hospitalization | 753 (11.8) | 235 (15.6)a | 176 (11.2)a | 49 (17.5)a | 10 (14.9)a | |
Hospital day | 55.6 ± 32.5 | 100.6 ± 51.4a | 95.2 ± 49.1a | 115.8 ± 55.0a | 130.3 ± 53.8a | |
Follow-up at CA 18-24 months (total n = 3,777) | ||||||
No. (%) | 2,960 (78.4) | 817 (21.6) | 608 (16.1) | 164 (4.3) | 45 (1.2) | |
Cerebral palsy | 25 (0.8) | 38 (4.7)a | 17 (2.8)a | 14 (8.5)a | 7 (15.6)a | |
MDI score (BSID-II) | 84.0 ± 23.7 | 83.3 ± 20.7 | ||||
Cognition score (BSID-III) | 97.4 ± 14.8 | 94.1 ± 17.5 | ||||
Language score (BSID-III) | 93.9 ± 15.2 | 90.6 ± 18.3 | ||||
Severe cognitive delay | 101 (3.4) | 41 (5.0)a | 27 (4.4)a | 13 (7.9)a | 1 (2.2) | |
PDI score (BSID-II) | 83.2 ± 22.0 | 84.9 ± 20.3 | ||||
Motor score (BSID-III) | 94.0 ± 16.5 | 90.4 ± 18.5 | ||||
Severe psychomotor delay | 80 (2.7) | 30 (3.3)a | 23 (3.8)a | 7 (4.3)a | 0 (0) | |
Neurosensory (hearing or visual) impairment | 10 (0.3) | 12 (1.5)a | 7 (1.2)a | 2 (1.2)a | 3 (6.7)a | |
Any neurodevelopmental impairment | 98 (3.3) | 40 (4.9)a | 28 (4.6)a | 8 (4.9)a | 4 (8.9)a |
Data are presented as mean ± standard deviation or number (%).
VLBW = very low birth weight, NICU = neonatal intensive care unit, CA = corrected age, MDI = mental developmental index, BSID = Bayley scales of infant development, PDI = psychomotor developmental index.
aCompared with no surgery.