Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 6;6(6):ENEURO.0229-18.2019. doi: 10.1523/ENEURO.0229-18.2019

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Klorig et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Figure 2. — Optogenetic train stimulation produces an AD. Kindling with daily oADs results in an overt behavioral seizure. A, Representative example of an optically-evoked AD. Top traces, Suprathreshold stimulation levels (for AD) produce network wide PDs (black traces). At subthreshold intensity levels, activation was observed only at the stimulation site (CA1-R; red traces). Middle traces, Zoomed out view of oAD. Bottom traces, pHFOs during oAD induction. B, oADs involve pHFOs across multiple sites with a non-zero phase lag. C, The probability of AD given at least × PDs occurring during the stimulus train. Inset, The overall probability of a PD on each pulse of the train, including subthreshold stimuli. Probabilities were calculated for each animal and the mean is displayed with 95% CIs, n = 7 animals. D, Seizure threshold remained stable throughout the kindling period. E, Behavioral seizure severity increased with each AD and was correlated with stimulation number.