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. 2019 Nov 6;6(6):ENEURO.0229-18.2019. doi: 10.1523/ENEURO.0229-18.2019

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Copyright © 2019 Klorig et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — The I50 is sensitive to changes in network excitability. A, The relationship between pre-seizure I50 and the 1st oADT (purple) or the average oADT throughout 15 kindling sessions (green). B, C, The GABAa antagonist PTZ (20 mg/kg) shifts the oPD curve leftward and treatment with the anticonvulsant drug LEV (40 mg/kg) partially reverses the shift; n = 6 animals; ***p = 0.00043, **p = 0.0034. Curve error bars indicate the 95% CI. D, E, Handling and intraperitoneal saline administration did not significantly shift the oPD curve compared to baseline (paired t test, n = 7). F, I50 measurements reveal the time course of PTZ-induced hyperexcitability (disinhibition). Plot of the I50 over time. Six block bins, n = 9 presentations of each condition (three trials × three animals). Shaded area is mean ± 95% CI.