Figure 2.

Analysis of glomeruli transcriptome revealed altered expression of genes involved in diverse podocyte-specific processes or being part of the circadian clock core. mRNA expression profiles of Tcf21, Nsf, Arhgap24, Ctsl, Sulf2, Gprc5a, Aff3, Cry1 and Npas2 in Control (black) and cKO (red) glomeruli. Values are means ± SEM. Statistical analyses were performed with the R package limma⁴⁸. Contrasts between cKO and Control at each time point were combined into one F-test. *Time point with difference after post-hoc classification of significant genes (false discovery rate <5%). n = 6 mice/time-point/genotype.