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. 2019 Nov 6;9:16089. doi: 10.1038/s41598-019-52682-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Urinary creatinine excretion during the inactive (light) phase (ZT0-ZT11) is higher in cKO mice. Profiles of every-hour urinary creatinine excretion in Control (black) and cKO (red) mice in (A) baseline (before DOX treatment) and (B) one month after the end of the DOX treatment. Bar plots represent the percentage of 24-hour urinary creatinine excretion excreted during the inactive (light) phase (ZT0-ZT11). *p < 0.05 (unpaired t test). n = 10 for cKO mice after DOX treatment, n = 11 in all other groups.