Figure 5.

For 26 mutations with pre-existing T-cell responses, we ranked them in order of probability of presentation within their corresponding patients. The mutation rank of NetMHCpan 4.0 was measured by taking the minimum predicted rank across all mutation-spanning peptides. The number of predicted mutations ranked in the top 5, 10, and 20 by EDGE and MHCflurry were derived from Bulik-Sullivan et al. (27).