Normal and diffuse thyroid follicular hyperplasia in the thyroid gland of
urban Norway rats. Figure 8. Normal thyroid follicular
cells are low cuboidal and surround follicles that contain abundant,
homogeneous, eosinophilic colloid. H&E. Figure 9.
Affected thyroid follicular cells are cuboidal to low columnar and
surround follicles that lack colloid. H&E. Figure 10.
Normal immunostaining that is intense and intracytoplasmic within
follicular cells. Immunohistochemistry (IHC) for thyroglobulin.
Figure 11. Within affected hyperplastic cells,
immunostaining is weak, diffuse, and intracytoplasmic, consistent with
follicular cells. IHC for thyroglobulin. Figures 12, 13.
Scattered normal interstitial C cells have intense cytoplasmic
immunostaining, whereas hyperplastic follicular cells are negative. IHC
for calcitonin.