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(A) NO donors exerting biofilm-inhibitory effect (Barraud et al., 2006). (B) Sulfathiazole 20 and azathioprine 21; small molecules found to interfere with c-di-GMP biosynthesis by the group of Antoniani et al. (2010, 2013). (C) Compound identified as DGC inhibitor (DI) by Sambanthamoorthy et al. (2014). (D) Inhibitors of DGC discovered by Sambanthamoorthy et al. (2014).
