Figure 1.

hsa_circ_0092306 Was Upregulated in Gastric Cancer (GC)

(A) Volcano plot of differentially expressed circRNAs. Twenty-two upregulated circular RNAs and 92 downregulated circular RNAs were screened (red: upregulated, green: downregulated). (B) Heatmap showing the top 20 significant disordered circular RNAs in GEO: GSE78092; hsa_circ_0092306 was upregulated in GC tissues. (C) RNase R assay verified the circular RNA identification of hsa_circ_0092306 in GC tissues. (D) hsa_circ_0092306 was significantly upregulated in 45 paired GC and adjacent tissues. (E) Relatively higher expression of hsa_circ_0092306 existed in four GC cell lines (MKN-45, N87, HGC-27, and AZ521) compared with the human gastric mucosa cell (GES 1). *p < 0.05, **p < 0.01, and ***p < 0.001 meant statistical significance.