Figure 6.

PRKCB Was the Downstream Functional Gene of hsa_circ_0092306/miR-197-3p in MKN-45 Cells

(A and B) The PKCβ1 protein (A) and PRKCB mRNA (B) levels after regulating miR-197-3p or hsa_circ_0092306 in MKN-45 cells were detected by western blot and quantitative real-time PCR, respectively. (C) Flow cytometry showed that PRCKB inhibited cell apoptosis in MKN-45 cells. (D) Cell viability measured by MTT showed a higher cell viability of MKN-45 cells in the PRCKB-overexpressed group. (E) Wound healing and Transwell assays showed higher cell migration and invasion in the PRCKB overexpression group. *p < 0.05, **p < 0.01, and ***p < 0.001 meant statistical significance.