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. 2019 Oct 1;15:153–165. doi: 10.1016/j.omto.2019.09.004

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Neurovirulence Evaluation of Ld0-GFP in BALB/c Mice

(A) Treatment scheme. i.c., intracerebral. BALB/c mice were injected with KOS, d0-GFP, and Ld0-GFP viruses at the indicated dosage and followed for survival. (B) Survival analysis of BALB/c mice after treatment. (C) H&E staining of whole brains from vehicle-, KOS-, d0-GFP-, and Ld0-GFP-injected mice on day 1, 5, 15, and 30 following virus injection. Red box represents injured areas. Scale bars, 200 μm. Data for survival were analyzed by the log-rank (Mantel-Cox) test. All values are presented as the mean ± SEM. ****p < 0.0001.