Table 2.
Patient Serologic Responses to a Single Dose of Intravenous Seprehvir
| Patient No. | WBC | ANC | ALC | HSV-1 PCR Blood | HSV-1 Seroconversion (IgG/IgM) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day | S | S | S | S | 0a | 1 | 4 | 7 | 14 | 21 | 28 | S | 28 |
| HSV01 | 9.1 | 5,600 | 1,638 | − | − | − | + | + | + | NA | NA | − | NA |
| HSV02 | 6.2 | 4,030 | 1,612 | − | − | − | + | − | − | − | − | − | +IgM |
| HSV03 | 13.5 | 9,585 | 1,620 | − | − | − | − | ND | ND | ND | ND | − | ND |
| HSV04 | 4.2 | 2,772 | 966 | − | − | − | − | − | − | − | + | − | +IgM |
| HSV05 | 5.4 | 3,078 | 864 | − | − | − | − | − | ND | ND | ND | − | ND |
| HSV06 | 5.8 | 5,046 | 348 | − | − | − | + | + | + | + | − | − | ND |
| HSV07 | 3.5 | 2,100 | 910 | − | − | − | − | − | − | − | − | − | +IgM |
| HSV08 | 8.8 | 5,280 | 2,376 | − | + | + | + | + | − | + | + | − | +IgM, +IgG |
| HSV09 | 4.6 | 3,634 | 414 | − | − | − | − | − | − | − | − | − | +IgM |
| HSV09-II | 4.7 | 3,384 | 705 | − | +b | − | − | − | − | − | − | +IgM | +IgM, +IgG |
ALC, absolute lymphocyte count; ANC, absolute neutrophil count; NA, not applicable (patient deceased); ND, not done; S, screening; WBC, white blood cell count.
a
Measured at 3, 6, and 18 h after virus injection.
b
Measured only at 3 h after virus injection.